Once you have access to a frame, you can manipulate most of its settings through the properties you can find in the DOM documentation.

You can apply this based on your choice of logic:

Registering to SelectedFrameChanged, and working on "document.selectedFrame"
Looping through all frames based on a type (Editor Enumerations - FrameType)
Finding frames in the document based on a tag
...

Frame Properties

All frames inherit the properties from the base frame object: Document Object Model - Frame

Individual frame types have their own classes (eg: Document Object Model - TextFrame)

Frame Constraints

Frame constraints can be configured on a variety of levels (document, page, layer, frame), and all are accessible through JavaScript.You can find the available constraint settings in ?Document Object Model - FrameConstraints

The following sample loops through all image frames in the document, and locks them for the end user:

function defaultLock()
{
    var totalFrames = 0; ;
    var numPages = editor.GetObject("document.pages").length;
    for (var i = 0; i < numPages; i++)
    {
        var numFrames = editor.GetObject("document.pages[" + i + "].frames").length;
        totalFrames = totalFrames + numFrames;
        for (var j = 0; j < numFrames; j++)
        {
            var type = editor.GetObject("document.pages[" + i + "].frames[" + j + "].type");
            if (type == "image")
            {
                editor.SetProperty("document.pages[" + i + "].frames[" + j + "].frameConstraints", "lockContent", "no");
                editor.SetProperty("document.pages[" + i + "].frames[" + j + "].frameConstraints", "lockDelete", "yes_users");
                editor.SetProperty("document.pages[" + i + "].frames[" + j + "].frameConstraints", "lockFrameSettings", "yes_users");
                editor.SetProperty("document.pages[" + i + "].frames[" + j + "].frameConstraints", "lockMoveHorizontal", "yes_users");
                editor.SetProperty("document.pages[" + i + "].frames[" + j + "].frameConstraints", "lockMoveVertical", "yes_users");
                editor.SetProperty("document.pages[" + i + "].frames[" + j + "].frameConstraints", "lockResizeHorizontal", "yes_users");
                editor.SetProperty("document.pages[" + i + "].frames[" + j + "].frameConstraints", "lockResizeVertical", "yes_users");
                editor.SetProperty("document.pages[" + i + "].frames[" + j + "].frameConstraints", "lockRotate", "yes_users");
            }
        }
    }
}

Assigning Shapes to a Frame

A shape has to exist within the workspace, in order to use JS to assign a shape to a frame.

// Get the shape object from the workspace
var shapePath = editor.GetObject('document.workSpace.defaultShapes[2]');
// Assign shape to the selected frame
editor.ExecuteFunction("document.selectedFrame", "SetPaths", shapePath.paths);

 
//unassign a shape to the frame
editor.ExecuteFunction("document.selectedFrame","SetPaths",null);

Frame Index Setting

You can change the frame's index by using the following JS, The high index 5000 indicates to put the frame on top, the low index 0 indicates to put the frame at the bottom

editor.SetProperty('document.allFrames[0]','index','5000');
editor.SetProperty('document.selectedFrame','index','0');

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